Inflammation Science Abstracts
1. Indian J Chest Dis Allied Sci. 1999 Jan-Mar;41(1):15-26.
Decreased sodium-potassium and calcium adenosine triphosphatase activity in asthma: modulation by inhaled and oral corticosteroids.
Chhabra SK, Khanduja A, Jain D.
Source
Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi.
Abstract
This study investigates the impact of corticosteroids on Na+/K+-ATPase and Ca2+-ATPase activities in asthma. Both inhaled and oral corticosteroids improved ATPase activity, reduced intracellular calcium, and decreased plasma lysophosphatidylcholine levels. These findings highlight the role of calcium homeostasis in managing asthma.
2. Clin Sci (Lond). 1999 Nov;97(5):595-601.
Increased intracellular calcium and decreased activities of leucocyte Na+,K+-ATPase and Ca2+-ATPase in asthma.
Chhabra SK, Khanduja A, Jain D.
Source
Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Abstract
This study analyzed intracellular calcium concentration and regulatory enzyme activities in asthmatics. Increased intracellular calcium and decreased Na+/K+-ATPase and Ca2+-ATPase activities were linked to asthma severity. Plasma lysophosphatidylcholine levels were also elevated, correlating with reduced lung function.
3. Intern Med. 1995 Aug;34(8):722-7.
Evidence for an increased intracellular free calcium concentration in platelets of bronchial asthma patients.
Kuroda S, et al.
Source
Department of Clinical Research, National Okura Hospital, Tokyo.
Abstract
This study showed elevated intracellular calcium levels in platelets of asthma patients compared to controls. The findings suggest that increased intracellular calcium may contribute to airway smooth muscle contraction, playing a role in asthma pathogenesis.
4. Inflamm Res. 1996 Dec;45(12):583-9.
Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells.
Akasaka R, et al.
Source
Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan.
Abstract
Ca2+-ATPase inhibitors were shown to elevate intracellular calcium levels and leukotriene release in mast cells. These findings suggest independent pathways for degranulation and leukotriene release mediated by calcium signaling.
5. Biochem Pharmacol. 1996 Jun 14;51(11):1513-9.
Effects of hydroquinone-type and phenolic antioxidants on calcium signals and degranulation of RBL-2H3 cells.
Akasaka R, et al.
Source
Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan.
Abstract
Hydroquinone-type antioxidants were found to increase intracellular calcium levels and enhance degranulation in mast cells. The results indicate a potential mechanism through calcium signaling for their effect on allergic responses.
