Bladder Science Abstracts
1. J Physiol. 2002 Jan 15;538(Pt 2):357-69.
The role of the L-type Ca(2+) channel in refilling functional intracellular Ca(2+) stores in guinea-pig detrusor smooth muscle.
Source
Department of Medicine, University College London, UK.
Abstract
This study investigates the role of L-type Ca(2+) channels in refilling intracellular Ca(2+) stores in detrusor smooth muscle cells. Findings show that store refilling occurs through Ca(2+) influx via these channels, regulated by a feedback mechanism. The study highlights the dependence of intracellular Ca(2+) stores on membrane depolarization and Ca(2+)-ATPase activity for maintaining contractile function.
2. Urology. 2009 Sep;74(3):691-6. Epub 2009 Jun 7.
The effect of 2- and 4-week ovariectomy on female rabbit urinary bladder function.
Source
Albany College of Pharmacy, Albany, NY, USA.
Abstract
This study evaluates the effects of ovariectomy (OVX) on bladder function in female rabbits. OVX led to decreased bladder weight, reduced contractile responses, and diminished mitochondrial and sarcoplasmic reticular function. These changes were linked to impaired blood flow and oxidative stress, suggesting that OVX significantly impacts detrusor muscle functionality.
3. Mol Cell Biochem. 2007 Dec;306(1-2):213-9. Epub 2007 Aug 3.
Effect of aging on the response of biochemical markers in the rabbit subjected to short-term partial bladder obstruction.
Source
Department of Pediatric Surgery, Gulhane Military Medical Faculty, Turkey.
Abstract
The study compares the impact of partial bladder outlet obstruction on young versus old rabbits. Results show that older rabbits exhibit significant declines in mitochondrial and SR function, indicating reduced adaptive capacity compared to younger rabbits. These findings underline the effects of aging on bladder dysfunction.
4. Pharmacology. 1997 Dec;55(6):309-16.
Subcellular distribution of SERCA and calcium-activated ATPase in rabbit and human urinary bladder smooth muscle.
Levin RM, et al.
Source
Department of Biological Science, Albany College of Pharmacy, NY, USA.
Abstract
SERCA plays a crucial role in bladder smooth muscle function. This study shows that SERCA concentrations are higher in microsomal fractions of rabbit and human bladder tissues, though enzymatic activity is greater in rabbit tissues. The findings support the importance of SERCA in smooth muscle functionality.
5. J Urol. 1997 Feb;157(2):732-8.
Calcium regulation of urinary bladder function.
Damaser MS, et al.
Source
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, USA.
Abstract
Bladder pressure generation relies on extracellular calcium influx and intracellular calcium release. The study highlights how calcium channel blockers (diltiazem) and SR inhibitors (thapsigargin) differentially affect pressure generation and bladder emptying, emphasizing the role of calcium regulation in bladder function.
